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Urokinase-type plasminogen activator and urokinase-type plasminogen activator receptor (uPA and uPAR) The binding of urokinase-type plasminogen activator (uPA) with urokinase-type plasminogen activator receptor (uPAR) is involved in the proteolytic activation of plasmin, which degrades fibrin and other ECM components, activating matrix metalloproteinases and promoting cell migration [172]